What supplements should I take with Mounjaro, Ozempic, or Wegovy?

If you’re using Mounjaro, Ozempic or Wegovy, you’ll probably recognise the shift. Less food noise. Fewer cravings. A sense of calm and control that feels genuinely liberating. For many women, it’s not about restriction – it’s about freedom and feeling more confident.

But when your appetite changes, you no doubt have a few questions. In fact, we spoke to women using weight loss injections about what really matters to them, and one theme kept coming up: nutrition. Many are juggling multiple supplements (often costing over £100 a month) just to feel covered.

This article looks at the best supplements to support weight loss, why they matter, and how to approach them sensibly, alongside real food.

*This article was reviewed by our senior scientist,  Dr Dave Reilly , in January 2026

Weight loss injections work by reducing appetite and slowing digestion. For many people, that means eating less – sometimes much less – than before. And while weight change can be intentional and positive, not eating enough food can also make it harder to consistently hit your nutritional needs.

Protein intake often drops first. Fibre can fall away when meals get smaller. Vitamins and minerals that rely on regular, varied eating patterns can become patchy. Over time, this may show up as low energy, changes in muscle tone, skin or hair changes, or impact on your digestion.

That’s where supplements that support weight loss can play a role – not as a replacement for food, but as nutritional support during a period of change. In fact, they’re most effective when paired with a balanced, nutrient-dense diet that prioritises protein, plants, healthy fats, and regular hydration.

1. Collagen
   Collagen is the body’s main structural protein. It’s the scaffolding that keeps skin feeling firm, hair looking healthy, and joints moving comfortably. It’s also something we naturally make less of as we get older. Add weight change into the mix and skin can feel like it’s playing catch-up, with elasticity and firmness shifting as your body adjusts.
   
   By taking collagen supplements , you can help support your skin structure and hair health while you’re using weight loss injections. But don’t just take our word for it, our clinical study revealed that 60% of participants experienced a boost in skin elasticity, while 90% agreed that their skin felt replenished and restored.
   
2. Electrolytes
   Electrolytes are essentially your body’s natural electrical wiring, performing countless critical functions that keep you alive and well. However, when we eat less and drink more water – which is really common on weight loss injections – we can sometimes dilute our electrolyte levels.
   
   If you’re regularly feeling fatigued or a bit lightheaded while taking Mounjaro, Ozempic, or Wegovy, try taking electrolyte supplements, as well as eating plenty of fruit and veg at mealtimes.
   
3. Fibre
   Fibre supports digestion and a healthy gut – both of which can be affected when your appetite is suppressed by weight loss injections. Eating less often means fewer natural fibre sources, particularly from wholegrains, vegetables, and legumes.
   
   Fibre supplements can help maintain intake when portions shrink, supporting digestive comfort and helping food move through the gut normally. Fibre also plays a role in feeding beneficial gut bacteria, which still need lots of fuel, even when you’re consuming fewer calories.
   
4. Protein
   Protein is essential for maintaining muscle tissue, skin structure, and everyday repair processes. And during weight loss, these protein needs don’t disappear – if anything, they become more important.
   
   When you don’t have an appetite, protein-rich foods can feel harder to include in your diet, especially if meals feel smaller or less appealing. Whether as a protein powder or as part of a multivitamin, take this supplement with Mounjaro, Wegovy, or Ozempic to help support muscle tone and strength during periods of rapid weight change, without worrying about adding too much to your plate.
   
5. Magnesium
   Magnesium is important for hundreds of biochemical reactions in your body, supporting muscle function, electrolyte balance, and energy metabolism. Yet, even with normal appetites, many people do not get enough magnesium in their daily diet.
   By supplementing magnesium, you can keep your energy levels high and feel strong in your body while using weight loss injections. You can also try snacking on almonds, peanuts, or pumpkin seeds as a quick magnesium-rich pick-me-up.
   
6. Vitamin B12
   Vitamin B12 not only helps support your nervous system, but it also helps to release energy from food. If you’re not eating enough of this nutrient – which commonly happens when appetite dips – you can often feel tired, sluggish, or lacking energy.
   To help maintain normal energy levels while taking Mounjaro, Ozempic, or Wegovy, try taking B12 supplements alongside eating meat, fish, and dairy in your regular meals.
   
   Weight loss injections can change how you eat – but they don’t change what your body needs. Explore  our blog  for more expert-led guidance on nutrition, skin health, and thriving through change.